"But they should not be seen as barriers for closer relations between us," he said.
Spokesman Wang Wenbin made the remarks at a press briefing when asked to comment on reports saying the United States plans to sell arms to Taiwan again.
The construction of the 1,000-km railway started in Dec. 2016, which is scheduled to be operational by the end of 2021.
Cao said in as early as January, the cooperation zone started to take precautionary measures against COVID-19, and a headquarters was established to make anti-coronavirus plans.
In the past 40 years, bilateral trade between China and the United States has increased dramatically, from a negligible 2.5 billion U.S. dollars in the late 1970s to the incredible amount of over 630 billion dollars in 2018.
China has a huge presence in the U.S. market as well as investment, as does the United States in China, which proves there are "very deep trade ties" between the two, he noted.
"The root cause is that some American politicians who are biased against and hostile to China are using their power to smear China with fabrications and impede normal ties with China under various pretexts," said Wang, pointing out that such American politicians ultimately want to drag China and the United States into renewed conflict and confrontation and plunge the world into chaos and division again.
Given its failure to tackle the COVID-19 health crisis, the Trump administration also tried to shift blame on the World Health Organization and pulled the United States out of the UN body.
The world will never want to see some U.S. political forces continue to undermine relations between the two countries and use Hong Kong to stir antagonism and hatred.
He recalled that leaders and statesmen of the elder generation in China and the United States acted in the fundamental interests of the two peoples and made the political decision of historic significance with their exceptional strategic vision and political courage to rise above the differences in ideology and social systems.
"A new Cold War between the United States and China would be something else entirely. It is difficult to see how it could be fought effectively, not to mention successfully," Coats said.