Koeman changed the style Barca used under Quique Setien, adapting a 4-2-3-1, with Antoine Griezmann leading the line, Frenkie de Jong and Sergio Busquets in the midfield holding roles and Messi, Philippe Coutinho and Ansu Fati in an attacking line of three.
There was drama in the last minute of injury time when Robin le Normand had the ball in the Valencia net only for the VAR to rule it out for handball.
The hosts did not stop, and created another amazing run, this time 14-0, on the way to a 44-33 lead in the 17th minute and 49-41 at half-time.
At Roland Garros, Djokovic has another record to achieve - becoming the first men's player in Open Era history to win each of the four Grand Slam titles at least twice.
Following reigning world champion Liu Shiwen's withdrawal due to an injury, her compatriot and current world No. 1 Chen Meng enters the action and expects a tough challenge from the closest rival Mima Ito from Japan.
LONDON, Sept. 29 (Xinhua) -- Chinese player Luo Honghao reached the second stage at the Snooker Championship League after claiming two victories and one draw in on Tuesday.
QINGDAO, China, Sept. 29 (Xinhua) -- Chinese swimmer Zhang Yufei broke the Asian record in the women's 100m butterfly in 55.62 seconds at the Chinese national swimming championships here on Tuesday.
The hosts dominated early as Jorge Recalde scored either side of a Carlos Sanchez penalty at the Manuel Ferreira stadium in Paraguayan capital Asuncion.
Thepchaiya Un-Nooh from Thailand won the other group on Saturday.
The 2016 French Open winner said at a press conference on his arrival in Paris that he would "make sure not to make the mistake twice."
Ranking fourth in the preliminary heat, Olympic champion Ye Shiwen failed to advance to the final of the women's 400m individual medley, as she failed to make the top eight in the physical tests, according to a new rule of the championships.